Hmm, maybe I’ll try to summarize the article and see if it helps.

Basically, the researchers in this study attempted to find out what the differences are between aggressive skin cancer (melanoma) cells that have spread to the brain and those that have spread to other organs.Surprisingly, they discovered that melanoma cells that spread to the brain survived and grew using a protein called amyloid-beta (Aβ).

Now, Aβ is known as the primary initiator that triggers the development of Alzheimer’s disease (AD). In AD, these Aβ are believed to cause chronic inflammation in the brain, leading to brain cell death and consequently, the progression of AD.

But what’s puzzling is that in this study, the authors found that the melanoma cancer cells in the brain produce Aβ. And instead of causing inflammation, these Aβs actually suppress inflammation.

As a transient inflammation is required to activate immune cells to eliminate foreign substances in the body, the lack of inflammation in this case means the brain’s immune cells will not be activated to attack the melanoma cancer cells, thus allowing them to thrive in the brain.

So this leaves us with an important question: what is the exact role of Aβ? Because knowing exactly what this protein does will help us come out with the best treatment for AD and melanoma-brain cancer.

I hope you find this helpful. :D