Thank you for reading through my work and leaving a thoughtful comment. That’s a great question; I’m glad you asked.

I came across two research papers, both of which are actually pre-prints (papers that have not yet been peer-reviewed) that study the process of antibody production that occurs after exposure to the coronavirus and after vaccination. The vaccines studied were the mRNA vaccine from Pfizer-BioNTech and the viral vector vaccine from AstraZeneca.

Interestingly, although both infection and vaccination lead to a similar outcome (generation of antibodies against SARS-CoV-2), they involve different pathways. That is, an infection needed IFNs to activate the adaptive immune system and generate antibodies, whereas mRNA vaccines use different routes that didn't involve IFNs to produce the antibodies. The covid vaccine from Aztrazeneca seems to involve a process similar to that of an infection.

However, I haven't found any information on whether the vaccines may cause any adverse effects, specifically in people who have these autoantibodies, since studies like this are scarce.

Indeed, I agree that this kind of research will provide important information to help create vaccines that offer the best benefits at little to no cost. And whether vaccines will or will not destroy natural immunity, I think this question will require many more years of research to answer.

On a lighter note, I think you asked a good question, and I hope I answered it. :D